FITC标记的A型流感病毒核衣壳蛋白抗体
产品名称： FITC标记的A型流感病毒核衣壳蛋白抗体
英文名称： Anti-H1N1+H5N1+H3N2 nucleocapsid protein/FITC
产品编号： HZ-4620R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-H1N1+H5N1+H3N2 nucleocapsid protein/FITC Conjugated antibody
FITC标记的A型流感病毒核衣壳蛋白抗体
| 英文名称 | Anti-H1N1+H5N1+H3N2 nucleocapsid protein/FITC |
| 中文名称 | FITC标记的A型流感病毒核衣壳蛋白抗体 |
| 别 名 | Influenza A virus(H1N1/H5N1/H3N2) |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 细菌及病毒 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | H1N1,H5N1,H3N2 |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 56kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from H1N1/H5N1/H3N2 nucleocapsid protein |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Influenza A virus is a major public health threat. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong. There was some evidence of human to human spread of this virus, but it is thought that the transmission efficiency was fairly low. HA interacts with cell surface proteins containing oligosaccharides with terminal sialyl residues. Virus isolated from a human infected with the H5N1 strain in 1997 could bind to oligosaccharides from human as well as avian sources, indicating its species jumping ability. Function: Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
甲型流感病毒是一种重大的公共健康威胁。由遗传漂变和病毒重组引起的新流感病毒株周期性地出现，人类几乎没有或没有免疫力，导致毁灭性的大流行。甲型流感病毒可存在于多种动物中，但在鸟类中，可发现所有亚型。这些亚型是基于病毒外壳glycoproteins hemagglutinin（HA）和神经氨酸酶（NA）亚型的组合进行分类的。1997年间，香港18名感染者中有6人死于H5N1禽流感病毒。有证据表明这种病毒的人与人传播，但人们认为传播效率相当低。HA与含有末端唾液酸残基的寡糖的细胞表面蛋白相互作用。从1997感染H5N1毒株的人中分离出的病毒能与人和禽类来源的寡糖结合，表明其物种跳跃能力。