FITC标记的细胞内氯离子通道蛋白4抗体
产品名称： FITC标记的细胞内氯离子通道蛋白4抗体
英文名称： Anti-CLIC4/FITC
产品编号： HZ-7098R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-CLIC4/FITC Conjugated antibody
FITC标记的细胞内氯离子通道蛋白4抗体
| 英文名称 | Anti-CLIC4/FITC |
| 中文名称 | FITC标记的细胞内氯离子通道蛋白4抗体 |
| 别 名 | MC3S5; Chloride intracellular channel 4; Chloride intracellular channel 4 (mitochondrial); Chloride intracellular channel 4 like; Chloride intracellular channel protein 4; Clic4; CLIC4_HUMAN; CLIC4L; DKFZP566G223; FLJ38640; H1 antibody HUH1; Intracellular chloride ion channel protein p64H1; mtCLIC; p64H1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 染色质和核信号 信号转导 细胞凋亡 通道蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 29kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CLIC4 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis. Tissue specificity: Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle. Function: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Subunit: Component of a multimeric complex consisting of several cytoskeletal proteins, including actin, ezrin, alpha-actinin, gelsolin, IQGAP1 and CLIC5A. Binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms. Monomer. Interacts with HRH3. Interacts with AKAP9. Subcellular Location: Cytoplasm, cytoskeleton, centrosome. Cytoplasmic vesicle membrane; Single-pass membrane protein (Probable). Nucleus matrix. Cell membrane; Single-pass membrane protein (Probable). Mitochondrion. Cell junction. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles. Tissue Specificity: Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle. Similarity: Belongs to the chloride channel CLIC family. Contains 1 GST C-terminal domain. Database links: Entrez Gene: 25932 Human Entrez Gene: 29876 Mouse Entrez Gene: 83718 Rat Omim: 606536 Human SwissProt: Q9Y696 Human SwissProt: Q9QYB1 Mouse SwissProt: Q9Z0W7 Rat Unigene: 440544 Human Unigene: 257765 Mouse Unigene: 104756 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
可以插入膜并形成低选择性离子通道，离子通道也可以传输氯离子。通道活性取决于pH。膜插入似乎是氧化还原调节的，并且可能仅发生在氧化条件下。促进HRH3细胞表面表达。在有丝分裂和胞质分裂过程中具有交替的细胞功能，如血管生成或维持心尖基底膜极性的潜在作用。还可以促进内皮细胞增殖和调节内皮形态发生。组织特异性：在结肠、食道和肾脏的上皮细胞中检测到（蛋白水平）。在心脏、肾脏、胎盘和骨骼肌中均有表达。