RPS6KB1 polyclonal antibody
产品名称： RPS6KB1 polyclonal antibody
英文名称： RPS6KB1 polyclonal antibody
产品编号： PAB18495
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of RPS6KB1.
- Immunogen:
- A synthetic peptide corresponding to residues surrounding S411 of human RPS6KB1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This antibody is specific to RPS6KB1.
- Form:
- Liquid
- Purification:
- Affinity purification
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Glycogen synthase kinase-3 interacts with and phosphorylates estrogen receptor alpha and is involved in the regulation of receptor activity.
Medunjanin S, Hermani A, De Servi B, Grisouard J, Rincke G, Mayer D.J Biol Chem. 2005 Sep 23;280(38):33006-14. Epub 2005 Aug 1.
- 2.
- Ligand-independent interactions of p160/steroid receptor coactivators and CREB-binding protein (CBP) with estrogen receptor-alpha: regulation by phosphorylation sites in the A/B region depends on other receptor domains.
Dutertre M, Smith CL.Mol Endocrinol. 2003 Jul;17(7):1296-314. Epub 2003 Apr 24.
- 3.
- Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes.
Krause U, Bertrand L, Hue L.Eur J Biochem. 2002 Aug;269(15):3751-9.
- 4.
- A new role for the p85-phosphatidylinositol 3-kinase regulatory subunit linking FRAP to p70 S6 kinase activation.
Gonzalez-Garcia A, Garrido E, Hernandez C, Alvarez B, Jimenez C, Cantrell DA, Pullen N, Carrera AC.J Biol Chem. 2002 Jan 11;277(2):1500-8. Epub 2001 Oct 29.
- 5.
- Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7.
Chen D, Riedl T, Washbrook E, Pace PE, Coombes RC, Egly JM, Ali S.Mol Cell. 2000 Jul;6(1):127-37.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of extracts from HeLa cells, untreated or treated with insulin (10 U/mL, 5 min), using RPS6KB1 polyclonal antibody (Cat # PAB18495).
Peptide "+" means "peptide blocking".
- Entrez GeneID:
- 6198
- Protein Accession#:
- P23443
- Gene Name:
- RPS6KB1
- Gene Alias:
- PS6K,S6K,S6K1,STK14A,p70(S6K)-alpha,p70-S6K,p70-alpha
- Gene Description:
- ribosomal protein S6 kinase, 70kDa, polypeptide 1
- Omim ID:
- 608938
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized. [provided by RefSeq
- Other Designations:
- p70 S6 kinase, alpha 1,p70 S6 kinase, alpha 2,ribosomal protein S6 kinase, 70kD, polypeptide 1,serine/threonine kinase 14 alpha