Recombinant Human ANGPTL-3
Catalog Number:
130-18
Synonyms:
Angiopoietin-like protein 3, ANG-5, ANGPT5
Description:
 
ANGPTL-3（血管生成素样蛋白3）是血管生成素(Angiopoitin)家族的成员之一，该家族蛋白均含一个卷曲的N-端结构域和一个C-端纤维蛋白原样结构域。ANGPTL-3主要在肝脏中表达，具有与血管生成和脂质代谢相关的活性。ANGPTL-3可抑制脂蛋白脂酶（LPL）和内皮脂酶（EL），从而具有增加甘油三酯和HDL相关胆固醇的血浆浓度的作用。ANGPTL-3蛋白的纤维蛋白原样结构域可以结合alpha-5/beta-3整合素，进而引起内皮细胞的黏附和迁移。重组人ANGPTL-3是糖蛋白,在SDS-PAGE电泳中呈现的表观分子量为62 kDa，含有452个氨基酸残基，其中包括C-端His标签。
 
AA Sequence:
SRIDQDNSSF DSLSPEPKSR FAMLDDVKIL ANGLLQLGHG LKDFVHKTKG QINDIFQKLN IFDQSFYDLS LQTSEIKEEE KELRRTTYKL QVKNEEVKNM SLELNSKLES LLEEKILLQQ KVKYLEEQLT NLIQNQPETP EHPEVTSLKT FVEKQDNSIK DLLQTVEDQY KQLNQQHSQI KEIENQLRRT SIQEPTEISL SSKPRAPRTT PFLQLNEIRN VKHDGIPAEC TTIYNRGEHT SGMYAIRPSN SQVFHVYCDV ISGSPWTLIQ HRIDGSQNFN ETWENYKYGF GRLDGEFWLG LEKIYSIVKQ SNYVLRIELE DWKDNKHYIE YSFYLGNHET NYTLHLVAIT GNVPNAIPEN KDLVFSTWDH KAKGHFNCPE GYSGGWWWHD ECGENNLNGK YNKPRAKSKP ERRRGLSWKS QNGRLYSIKS TKMLIHPTDS ESFEHHHHHH HH
Source:
CHO cells
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Measured by its binding ability to recombinant αvβ3 integrin in a functional ELISA. 
 
 
 
 
Research Interests:
Angiogenesis/ Cardiovascular
Diabetes / Weight Regulation
Lipid Metabolism
 
 
 
Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.