FITC标记的FGD3蛋白抗体
产品名称： FITC标记的FGD3蛋白抗体
英文名称： Anti-FGD3/FITC
产品编号： HZ-16079R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-FGD3/FITC Conjugated antibody
| FITC标记的FGD3蛋白抗体 |
| 英文名称 | Anti-FGD3/FITC |
| 中文名称 | FITC标记的FGD3蛋白抗体 |
| 别 名 | Faciogenital dysplasia 3; FGD1 family, member 3; FGD3; FGD3_HUMAN; FYVE; FYVE, RhoGEF and PH domain containing 3; FYVE, RhoGEF and PH domain containing protein 3; RhoGEF and PH domain-containing protein 3; ZFYVE5; Zinc finger FYVE domain containing protein 5; Zinc finger FYVE domain-containing protein 5. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞膜受体 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 79kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FGD3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: FGD1 gene mutations result in faciogenital dysplasia (FGDY, Aarskog-Scott syndrome), an X-linked developmental disorder that adversely affects the formation of multiple skeletal structures. FGD1 maps to human chromosome Xp11.21 and shares a high degree of sequence identity with the FGD2 (6p21.2) and the FGD3 (9q22.31) proteins. FGD1 encodes a guanine nucleotide exchange factor that specifically activates the Rho GTPase Cdc42. FGD2 is present in several diverse tissues during embryogenesis, suggesting a role in embryonic development. FGD3 stimulates fibroblasts to form filopodia, which are Actin microspikes formed upon the stimulation of Cdc42. All FGD family members contain equivalent signaling domains and a conserved structural organization, which strongly suggests that these signaling domains form a canonical core structure for members of the FGD family of RhoGEF proteins. These proteins control essential signals required during embryonic development. Function: Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Subcellular Location: Cytoplasm. Cytoplasm > cytoskeleton. Similarity: Contains 1 DH (DBL-homology) domain. Contains 1 FYVE-type zinc finger. Contains 2 PH domains. Database links: Entrez Gene: 89846 Human Entrez Gene: 30938 Mouse Entrez Gene: 361223 Rat SwissProt: Q5JSP0 Human SwissProt: O88842 Mouse Unigene: 411081 Human Unigene: 291089 Mouse Unigene: 214480 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
FGD1基因突变导致面源性发育不良（FGDY，Aarskog-Scott综合征），一种X连锁的发育障碍，不利地影响多骨骼结构的形成。FGD1定位于人类染色体Xp11.21，与FGD2(6p21.2)和FGD3(9q22.31)蛋白具有高度的序列同一性。FGD1编码鸟嘌呤核苷酸交换因子，特异性激活Rho GTP酶CDC42。FGD2存在于胚胎发育过程中的多种不同组织中，提示胚胎发育中的作用。FGD3刺激成纤维细胞形成丝状伪足，这是在刺激CDC42时形成的肌动蛋白微棘。所有FGD家族成员都含有等效的信号结构域和保守的结构结构，这强烈表明这些信号结构域构成了RhoGEF蛋白FGD家族成员的典型核心结构。这些蛋白质控制胚胎发育过程中必需的信号。