IL2RA monoclonal antibody, clone MEM-181 (PE)
产品名称： IL2RA monoclonal antibody, clone MEM-181 (PE)
英文名称： IL2RA monoclonal antibody, clone MEM-181 (PE)
产品编号： MAB4585
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native IL2RA.
- Immunogen:
- Native purified IL2RA from PHA-activated peripheral blood leucocytes.
- Host:
- Mouse
- Theoretical MW (kDa):
- 55
- Reactivity:
- Human
- Specificity:
- This antibody reacts with CD25 (Interleukin-2 receptor alpha chain), a 55 KDa type I transmembrane glycoprotein expressed on activated B and T lymphocytes, activated monocytes/macrophages and on CD4+ T lymphocytes (T regulatory cells); it is lost on resting B and T lymphocytes.
- Form:
- Liquid
- Conjugation:
- PE
- Isotype:
- IgG1
- Storage Buffer:
- In PBS (0.2% BSA, 15 mM sodium azide)
- Storage Instruction:
- Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- CD25 indicates the neoplastic phenotype of mast cells: a novel immunohistochemical marker for the diagnosis of systemic mastocytosis (SM) in routinely processed bone marrow biopsy specimens.
Sotlar K, Horny HP, Simonitsch I, Krokowski M, Aichberger KJ, Mayerhofer M, Printz D, Fritsch G, Valent P.Am J Surg Pathol. 2004 Oct;28(10):1319-25.
- 2.
- Advances in interleukin 2 receptor targeted treatment.
Morris JC, Waldmann TA.Ann Rheum Dis. 2000 Nov;59 Suppl 1:i109-14.
- 3.
- The interleukin-2 receptor in human monocytes and macrophages: regulation of expression and release of the alpha and beta chains (p55 and p75).
Scheibenbogen C, Keilholz U, Richter M, Andreesen R, Hunstein W.Res Immunol. 1992 Jan;143(1):33-7.
- Application Image
- Flow Cytometry
- Entrez GeneID:
- 3559
- Gene Name:
- IL2RA
- Gene Alias:
- CD25,IDDM10,IL2R,TCGFR
- Gene Description:
- interleukin 2 receptor, alpha
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. [provided by RefSeq
- Other Designations:
- Interleukin-2 receptor,OTTHUMP00000019030,OTTHUMP00000044870,interleukin 2 receptor, alpha chain
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- Acquired Immunodeficiency Syndrome
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- Alzheimer Disease
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- Asthma
- Asthma
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- Autoimmune Diseases
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- Cardiovascular Diseases
- Celiac Disease
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