FITC标记的B淋巴细胞基因1抗体
产品名称： FITC标记的B淋巴细胞基因1抗体
英文名称： Anti-TLE4/FITC
产品编号： HZ-12403R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-TLE4/FITC Conjugated antibody
FITC标记的B淋巴细胞基因1抗体
| 英文名称 | Anti-TLE4/FITC |
| 中文名称 | FITC标记的B淋巴细胞基因1抗体 |
| 别 名 | B lymphocyte gene 1; B lymphocyte gene 1; enhancer of split groucho 4; enhancer of split groucho 4; ESG4; ESG4; KIAA1261; TIM; TIM1; timeless (Drosophila) homolog; TLE4; transducin-like enhancer of split 4; transducin-like enhancer of split 4; TLE4_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 染色质和核信号 神经生物学 信号转导 干细胞 转录调节因子 细胞分化 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 84kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TLE4 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates. Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, also designated ESG for enhancer of split groucho), which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. TLEs associate with chromatin in live cells and specifically with Histone H3, but not with other core histones. Expression of the TLE genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, suggesting a role during epithelial differentiation. TLE1, TLE2 and TLE3 have elevated expression in cervical squamous metaplasias and carcinomas, while TLE4 is most highly expressed in the brain, particularly in the caudate nucleus. TLE1 and TLE4 contain SP and WD40 domains, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor. In early stages of cell differentiation, TLE1 is upregulated, and TLE2 and TLE4 are downregulated. In later stages, TLE2 and TLE4 are upregulated, and expression of TLE1 decreases. Function: TLE4 (Transducin-like enhancer protein 4) is a member of the Groucho family of transcriptional corepressors and inhibits the transcriptional activation mediated by Pax5 and by beta-catenin and TCF family members in Wnt signaling. Subunit: Homooligomer and heterooligomer with other family members. Binds PAX5, LEF1, TCF7, TCF7L1 and TCF7L2. Interacts with ZNF703; TLE4 may mediate ZNF703 transcriptional repression. Subcellular Location: Nuclear Tissue Specificity: In all tissues examined, mostly in brain, and muscle. Post-translational modifications: Phosphorylated. PAX5 binding increases phosphorylation. Ubiquitinated by XIAP/BIRC4. Similarity: Belongs to the WD repeat Groucho/TLE family. Contains 7 WD repeats. Database links: Entrez Gene: 7091 Human Entrez Gene: 21888 Mouse Entrez Gene: 25565 Rat Omim: 605132 Human SwissProt: Q04727 Human SwissProt: Q62441 Mouse SwissProt: Q07141 Rat Unigene: 444213 Human Unigene: 103638 Mouse Unigene: 53972 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Notch信号通路控制着细胞间的相互作用，这种相互作用对于无脊椎动物和脊椎动物的各种命运的规范都很重要。Notch途径的关键参与者是TLE基因（用于分裂的转导素样增强子，也指定ESG用于分裂的腹股沟增强子），它们是果蝇腹股沟基因的人类同源物。格劳乔是一个转录阻遏物，在神经发生、分割和性别决定中起着关键作用。TLE与染色质在活细胞，特别是组蛋白H3，但不与其他核心组蛋白。TLE基因TLE1、TLE2、TLE3和TLE4的表达与正在向终末分化状态进展的未成熟上皮细胞相关，表明在上皮分化过程中起作用。TLE1、TLE2和TLE3在宫颈鳞状上皮化生和癌中表达升高，而TLE4在大脑中表达最高，尤其是在尾状核中。TLE1和TLE4含有SP和WD40结构域，TLE1通过它们结合AML1来抑制AML1诱导的CSF1受体反式激活。在细胞分化的早期阶段，TLE1上调，TLE2和TLE4下调。在后期，TLE2和TLE4上调，TLE1表达减少。