FITC标记的C型凝集素结构域家族1成员B抗体
产品名称： FITC标记的C型凝集素结构域家族1成员B抗体
英文名称： Anti-CLEC2/FITC
产品编号： HZ-2543R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-CLEC2/FITC Conjugated antibody
FITC标记的C型凝集素结构域家族1成员B抗体
| 英文名称 | Anti-CLEC2/FITC |
| 中文名称 | FITC标记的C型凝集素结构域家族1成员B抗体 |
| 别 名 | C-type lectin domain family 1 member B; 1810061I13Rik; C type lectin domain family 1 member B; C type lectin like receptor 2; C-type lectin domain family 1, member B; C-type lectin-like receptor-2; CLEC 2; CLEC 2B; CLEC-2; CLEC2; CLEC2B; PRO1384; QDED721; CLC1B_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, |
| 产品应用 | Flow-Cyt=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 27kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CLEC2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011] Function: Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets. Subunit: Homodimer. Subcellular Location: Membrane; Single-pass type II membrane protein (Probable). Tissue Specificity: Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets. Post-translational modifications: Glycosylated. Phosphorylated on tyrosine residue in response to rhodocytin binding. Similarity: Contains 1 C-type lectin domain. Database links: Entrez Gene: 51266 Human Omim: 606783 Human SwissProt: Q9P126 Human Unigene: 221418 Human Unigene: 409794 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
自然杀伤（NK）细胞表达多种钙依赖性（C型）凝集素样受体，如CD94（KLRD1；MIM 602894）和NKG2D（KLRC4；MIM 602893），它们与主要组织相容性复合体I类分子相互作用，抑制或激活细胞毒性和细胞因子分泌。CelEC2是髓系细胞和NK细胞中表达的C型凝集素样受体（Colonna等，2000 [PubMed 10671229 ]）[由OMIM，JAN 2011提供]。