MTOR Peptide
产品名称： MTOR Peptide
英文名称： MTOR Peptide
产品编号： P1883
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of FRAP1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to residues surrounding T2446 of human FRAP1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells.
Dowling RJ, Zakikhani M, Fantus IG, Pollak M, Sonenberg N.Cancer Res. 2007 Nov 15;67(22):10804-12.
- 2.
- Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance.
Zhou J, Wulfkuhle J, Zhang H, Gu P, Yang Y, Deng J, Margolick JB, Liotta LA, Petricoin E 3rd, Zhang Y.Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16158-63. Epub 2007 Oct 2.
- Applications
- Western Blot (Transfected lysate)
- Western blot analysis of MTOR (arrow) using rabbit MTOR polyclonal antibody (Cat # PAB4857). 293 cell lysate (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MTOR gene (Lane 2) (Origene Technologies).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with MTOR polyclonal antibody (Cat # PAB4857) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated.
- Entrez GeneID:
- 2475
- Protein Accession#:
- NP_004949;P42345
- Gene Name:
- MTOR
- Gene Alias:
- FRAP,FRAP1,FRAP2,RAFT1,RAPT1
- Gene Description:
- mechanistic target of rapamycin
- Omim ID:
- 601231
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq
- Other Designations:
- FK506 binding protein 12-rapamycin associated protein 1,FK506 binding protein 12-rapamycin associated protein 2,FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP-rapamycin associated protein,FKBP12-rapamycin complex-associated protein 1