FITC标记的酰基辅酶A合成酶4抗体
产品名称： FITC标记的酰基辅酶A合成酶4抗体
英文名称： Anti-FACL4/FITC
产品编号： HZ-13129R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-FACL4/FITC Conjugated antibody
FITC标记的酰基辅酶A合成酶4抗体
| 英文名称 | Anti-FACL4/FITC |
| 中文名称 | FITC标记的酰基辅酶A合成酶4抗体 |
| 别 名 | ACS 4; ACS4; ACSL 4; Acsl4; ACSL4_HUMAN; acyl CoA synthetase 4; Acyl CoA synthetase long chain family member 4; FACL 4; FACL4; Fatty acid Coenzyme A ligase; fatty acid Coenzyme A ligase long-chain 4; LACS 4; LACS4; Lignoceroyl CoA synthase; Long chain 4; long chain acyl CoA synthetase 4; long chain fatty acid CoA ligase 4; long chain fatty acid Coenzyme A ligase 4; Long-chain acyl-CoA synthetase 4; Long-chain-fatty-acid--CoA ligase 4; MRX63; MRX68. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 发育生物学 神经生物学 信号转导 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 79kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FACL4/ACSL4 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Acyl-CoA synthetases, also known as long-chain fatty-acid CoA synthases (FACL) or palmitoyl-CoA ligases, include ACSL1-6, which are all single-pass membrane proteins localizing to the mitochondrion, microsome or peroxisome. FACL proteins are important for synthesis of cellular lipids and for ∫-oxidation degradation. Specifically, ACSL proteins catalyze the activation of long-chain fatty acids to acyl-CoAs, which can be metabolized to form CO2, triacylglycerol (TAG), phospholipids (PL) and cholesteryl esters (CE). ACSL3 preferentially utilizes laurate, myristate, arachidonate and eicosapentaenoate among saturated and unsaturated long chain fatty acids. FACL3 is expressed as two isoforms in various tissues, including brain, heart, placenta, prostate, skeletal muscle, testis and thymus. FACL4 preferentially utilizes arachidonate and is abundant in steroidogenic tissues. FACL4 may modulate female fertility and uterine prostaglandin production. Function: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates. Subcellular Location: Mitochondrion outer membrane. Peroxisome membrane. Microsome membrane. Endoplasmic reticulum membrane. DISEASE: Defects in ACSL4 are the cause of mental retardation X-linked type 63 (MRX63) [MIM:300387]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. Defects in ACSL4 are involved in Alport syndrome with mental retardation midface hypoplasia and elliptocytosis (ATS-MR) [MIM:300194]. A X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, deafness, mental retardation, midface hypoplasia and elliptocytosis. Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. Database links: Entrez Gene: 2182 Human Entrez Gene: 50790 Mouse Entrez Gene: 113976 Rat Omim: 300157 Human SwissProt: O60488 Human SwissProt: Q9QUJ7 Mouse SwissProt: O35547 Rat Unigene: 268785 Human Unigene: 391337 Mouse Unigene: 87821 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
酰基辅酶A合成酶，也称为长链脂肪酸辅酶A合成酶（FACL）或棕榈酰辅酶A连接酶，包括ACSL1-6，它们都是定位于线粒体、微粒体或过氧化物酶体的单程膜蛋白。FACL蛋白对细胞脂质合成和氧化降解具有重要意义。具体而言，ACSL蛋白催化长链脂肪酸活化成酰基辅酶A，该酰基辅酶A可被代谢形成CO2、三酰甘油(TAG)、磷脂(PL)和胆固醇酯(CE)。ACSL3在饱和和不饱和长链脂肪酸中优先利用月桂酸酯、肉豆蔻酸酯、花生四烯酸酯和二十碳五烯酸酯。FACL3在大脑、心脏、胎盘、前列腺、骨骼肌、睾丸和胸腺等不同组织中以两种异构体表达。FACL4优先利用花生四烯酸和富含类固醇的组织。FACL4可调节女性生育能力和子宫前列腺素的产生。