FITC标记的突触素样蛋白1抗体
产品名称： FITC标记的突触素样蛋白1抗体
英文名称： Anti-Pantophysin/FITC
产品编号： HZ-7411R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Pantophysin/FITC Conjugated antibody
| FITC标记的突触素样蛋白1抗体 |
| 英文名称 | Anti-Pantophysin/FITC |
| 中文名称 | FITC标记的突触素样蛋白1抗体 |
| 别 名 | SYPL1_HUMAN; Synaptophysin-like protein 1; Pantophysin; SYPL1; H-SP1; SYPL. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 29kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Pantophysin |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The MARVEL domain is a 130 amino acid motif that contains four transmembrane helices, both of which have cytoplasmic N- and C-terminal regions. MARVEL domain-containing proteins are thought to participate in tight junction regulation, the biogenesis of vesicular transport carriers and in cholesterol-rich membrane apposition events. Pantophysin, also known as SYPL1 (synaptophysin-like protein 1) or H-SP1, is a 259 amino acid multi-pass membrane protein that localizes to melanosomes and vesicles, as well as to the cytoplasm, and contains one MARVEL domain. Expressed as multiple alternatively spliced isoforms, pantophysin is present in tissues throughout the body where it may play a role in vesicle trafficking and protein transport. The gene encoding pantophysin maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Defects in some of the genes localized to chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. Subcellular Location: Cytoplasmic vesicle membrane; Multi-pass membrane protein (By similarity). Melanosome. Note=Cytoplasmic transport vesicles (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Similarity: Belongs to the synaptophysin/synaptobrevin family. Contains 1 MARVEL domain. Database links: Entrez Gene: 6856 Human Entrez Gene: 19027 Mouse Entrez Gene: 366595 Rat SwissProt: Q16563 Human SwissProt: O09117 Mouse Unigene: 80919 Human Unigene: 246304 Mouse Unigene: 17193 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
MARVEL结构域是一个130个氨基酸基序，包含4个跨膜螺旋，它们都具有细胞质N端和C端区域。MARVEL结构域蛋白被认为参与紧密连接调节、囊泡运输载体的生物发生和富含胆固醇的膜同位事件。泛素蛋白，又称SYPL1(synaptophysin-like protein 1)或H-SP1，是一种259个氨基酸的多路膜蛋白，定位于黑色素体和小泡以及细胞质，并含有一个MARVEL结构域。表达为多种可选择的拼接异构体，泛素存在于全身的组织中，它在囊泡运输和蛋白质运输中可能发挥作用。编码泛素基因的基因定位于人类7号染色体，其中包含1000多个基因，占人类基因组的近5%。一些位于7号染色体的基因的缺陷与成骨不全、威廉斯-贝伦综合征、Pendred综合征、Lissencephaly、瓜氨酸血症和Shwachman-Diamond综合征有关。