FITC标记的GTP结合蛋白REM1抗体-抗体-抗体-生物在线
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FITC标记的GTP结合蛋白REM1抗体

FITC标记的GTP结合蛋白REM1抗体

商家询价

产品名称： FITC标记的GTP结合蛋白REM1抗体

英文名称： Anti-GTP binding protein REM1/FITC

产品编号： HZ-7502R-FITC

产品价格： null

产品产地： 中国/上海

品牌商标： HZbscience

更新时间： 2023-08-17T10:24:20

使用范围： IF=1:50-200

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 Rabbit Anti-GTP binding protein REM1/FITC Conjugated antibody

FITC标记的GTP结合蛋白REM1抗体

 

英文名称 Anti-GTP binding protein REM1/FITC
中文名称 FITC标记的GTP结合蛋白REM1抗体
别    名 Rad and Gem related GTP binding protein; GES; GTP binding protein REM; GTP binding protein REM 1; GTP binding protein REM1; GTPase GES; GTPase regulating endothelial cell sprouting; Rad and Gem like GTP binding protein 1; RAS (RAD and GEM) like GTP binding; RAS like GTP binding; RAS like GTP binding protein REM; REM 1; REM1; E030011C07Rik; RP23-35I8.9; GD:REM; MGC114556; MGC48669; OTTMUSP00000016855; REM1_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 心血管  细胞生物  信号转导  生长因子和激素  转录调节因子  通道蛋白  血管内皮细胞  G蛋白信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 33kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human REM/GTP binding protein REM1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
产品介绍 background:
REM (Rad and Gem related GTP binding protein) is a member of the Rad/Gem/Kir subfamily of Ras-like GTPases and shares with other members of this subfamily some unusual structural features. Among these are nonconservative amino acid substitutions within guanine nucleotide binding and hydrolysis domains, unique effector domains, extended N- and C-termini, and a conserved C-terminal sequence thought to mediate membrane association but lacking a classical isoprenylation motif. REM, with a predicted molecular weight of 32.9 kDa, is most highly expressed in cardiac muscle and is expressed at more moderate levels in lung, kidney and skeletal muscle. REM is phosphorylated in vivo and has been shown to interact with several 14-3-3 isoforms. It has been reported that the GTP-bound form of a related Ras-like GTPase, GEM/kir, inhibits high-voltage activated Ca2+ channel activities by interacting directly with the ?subunit. The reduced channel activities are the result of a decreased a-subunit expression at the plasma membrane. This inhibition of L-type Ca2+ channels prevents Ca2+-triggered exocytosis in hormone-secreting cells. There are data that suggest that REM similarly regulates Ca2+ channel expression.

Function:
Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling. 

Subunit:
In vitro, interacts with calmodulin in a calcium-dependent manner. 

Tissue Specificity:
Most highly expressed in the endothelial lining of the blood vessels in uterus and heart. Lower levels found in spleen, lymph node, kidney and testis. Also found in cells with secretory function such as the islets of Langerhans, lobule/duct epithelium in the breast, bile duct epithelium in the liver, surface epithelium in the endometrial glands of the uterus, colon mucosa and acinar cells in the pancreas and the prostate. 

Similarity:
Belongs to the small GTPase superfamily. RGK family.

Database links:
UniProtKB/Swiss-Prot: O75628.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application
   

REM（RAD和GEM相关的GTP结合蛋白）是Ras／GEM/KIR亚家族Ras样GTP酶的成员，与该亚家族的其他成员共享一些不寻常的结构特征。其中有非保守氨基酸取代在鸟嘌呤核苷酸结合和水解结构域，独特的效应域，扩展的N-和C-末端，和保守的C-末端序列认为介导膜结合，但缺乏经典的异戊二烯基序。REM，预测的分子量为32.9 kDa，最高表达在心肌中，在肺、肾和骨骼肌中表达得更适中。REM在体内磷酸化，并已被证明与几个14-3-3亚型相互作用。据报道，相关的Ras样GTPase，GEM/KIR的GTP结合形式，通过与……直接相互作用，抑制高电压激活的Ca2+通道活性。亚单位。减少的通道活性是在质膜上降低的α亚基表达的结果。这种抑制L型Ca2+通道可防止激素分泌细胞中Ca2+触发的胞吐作用。有数据表明，REM同样调节Ca2+通道的表达。