FITC标记的NUDT15蛋白抗体
产品名称： FITC标记的NUDT15蛋白抗体
英文名称： Anti-NUDT15/FITC
产品编号： HZ--4401R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-NUDT15/FITC Conjugated antibody
FITC标记的NUDT15蛋白抗体
| 英文名称 | Anti-NUDT15/FITC |
| 中文名称 | FITC标记的NUDT15蛋白抗体 |
| 别 名 | 8-dihydro-8-oxoguanine triphosphatase NUDT15; 8-oxo-dGTPase NUDT15; A730068G11Rik; EC 3.1.6.-; FLJ10956; MGC104352; MTH2; MutT homolog 2; Nucleoside diphosphate-linked moiety X motif 15; NUD15_HUMAN; Nudix (nucleoside diphosphate linked moiety X)-type motif; Nudix motif 15; NUDT15; OTTHUMP00000018389; Probable 7; Probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15; RP11-90M2.1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 19kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NUDT15 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | Function: Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA synthesis and cell cycle progression throught the interaction with PCNA. Similarity: Belongs to the Nudix hydrolase family. Contains 1 nudix hydrolase domain. Database links: Entrez Gene: 55270 Human Entrez Gene: 214254 Mouse Entrez Gene: 290365 Rat SwissProt: Q9NV35 Human SwissProt: Q8BG93 Mouse Unigene: 144407 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
介导某些核苷二磷酸衍生物的水解。在体外可降解8-氧代-dGTP，提示其可从DNA和核苷酸池中去除氧化损伤形式的鸟嘌呤（7，8-二氢-8-氧鸟嘌呤），从而防止8-氧代-dGTP误掺入DNA，从而防止A：T到C：G的颠倒。然而，其在体内的底物特异性尚不清楚（通过相似性）。可能通过与PCNA的相互作用在DNA合成和细胞周期进展中发挥作用。