LAMC1 monoclonal antibody, clone BC17
产品名称： LAMC1 monoclonal antibody, clone BC17
英文名称： LAMC1 monoclonal antibody, clone BC17
产品编号： MAB2519
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against partial native LAMC1.
- Immunogen:
- Native purified human LAMC1.
- Host:
- Mouse
- Reactivity:
- Human
- Specificity:
- This antibody recognizes the Mr 200,000 gamma1-chain of human reduced and alkylated laminin produced by various cultured cells, which produce laminins complexed with it. The specificity of Mab BC17 has been confirmed by immunoprecipitation and Elisa by using recombinant gamma1- chain. This antibody only reacts with human cells and tissues. The monoclonal antibody can be widely applied in immunohistochemical studies as all basement membranes contain laminin trimers containing these chains.
- Form:
- Liquid
- Isotype:
- IgG1
- Storage Buffer:
- In PBS (1% BSA, 0.1% sodium azide)
- Storage Instruction:
- Store at 4°C. Do not freeze.
- Quality Control Testing:
- Antibody Reactive Against Native Purified Protein.
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Chain specificity assignment of monoclonal antibodies to human laminins by using recombinant laminin beta1 and gamma1 chains.
Geberhiwot T, Wondimu Z, Salo S, Pikkarainen T, Kortesmaa J, Tryggvason K, Virtanen I, Patarroyo M.Matrix Biol. 2000 May;19(2):163-7.
- Application Image
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunoprecipitation
- Entrez GeneID:
- 3915
- Gene Name:
- LAMC1
- Gene Alias:
- LAMB2,MGC87297
- Gene Description:
- laminin, gamma 1 (formerly LAMB2)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis. [provided by RefSeq
- Other Designations:
- OTTHUMP00000033450,formerly LAMB2,laminin, gamma 1
- Related Disease