重组人泛素羧基末端水解酶14(USP14)

中文名称：重组人泛素羧基末端水解酶14(USP14)
英文名称：Recombinant Human Ubiquitin Carboxyl-Terminal Hydrolase 14
产品规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Asp91-Gln494在N端含有His标签。

USP14质量控制：＞95%(还原性SDS-PAGE)

USP14制剂：液体

USP14保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于USP14：
Ubiquitin Carboxyl-Terminal Hydrolase 14 (USP14) belongs to the ubiquitin-specific processing (USP) family which is a deubiquitinating enzyme (DUB) with His and Cys domains. USP14 located in the cytoplasm is a proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. USP14 acts also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. In addition, USP14 is indispensable for synaptic development and function at neuromuscular junctions, required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. 

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