GNE (Human) Recombinant Protein (Q01)
产品名称： GNE (Human) Recombinant Protein (Q01)
英文名称： GNE (Human) Recombinant Protein (Q01)
产品编号： H00010020-Q01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Human GNE partial ORF ( NP_005467, 1 a.a. - 110 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- MEKNGNNRKLRVCVATCNRADYSKLAPIMFGIKTEPEFFELDVVVLGSHLIDDYGNTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKLPDVLNRLKPDIMIVH
- Theoretical MW (kDa):
- 37.84
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
Download
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 10020
- GeneBank Accession#:
- NM_005476
- Protein Accession#:
- NP_005467
- Gene Name:
- GNE
- Gene Alias:
- DMRV,GLCNE,IBM2,NM,Uae1
- Gene Description:
- glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq
- Other Designations:
- N-acylmannosamine kinase,OTTHUMP00000021370,UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase,UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase
- Related Disease