FITC标记的PRAM1蛋白抗体
产品名称： FITC标记的PRAM1蛋白抗体
英文名称： Anti-PRAM1/FITC
产品编号： HZ-12676R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PRAM1/FITC Conjugated antibody
FITC标记的PRAM1蛋白抗体
| 英文名称 | Anti-PRAM1/FITC |
| 中文名称 | FITC标记的PRAM1蛋白抗体 |
| 别 名 | PML RAR; PML RARA regulated adaptor molecule 1; PML RARA target gene encoding an Adaptor Molecule 1; PML-RARA-regulated adapter molecule 1; PRAM 1; PRAM; PRAM-1; PRAM_HUMAN; PRAM1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 信号转导 激酶和磷酸酶 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 79kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PRAM1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Complete remission of acute promyelocytic leukemia can be achieved by treating patients with retinoic acid, and PML-RAR-a (promyelocytic leukemia-retinoic acid receptor alpha fusion protein) plays a major role in mediating retinoic acid effects in leukemia cells. The retinoic acid-induced gene, PRAM-1 (PML-RAR-a target gene encoding an adaptor molecule 1) encodes an adaptor protein which is expressed and modulated during normal human myelopoiesis. PRAM-1 expression is hindered by expression of PML-RAR-a. The 718 amino acid PRAM-1 protein contains eight N-terminal proline-rich repeats and several proline residues that are clustered as type I or type II SH3 recognition motifs. PRAM-1 demonstrates expression in hematopoietic tissues and lung. Function: May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P. Tissue Specificity: Expressed in peripheral blood leukocytes and bone marrow. Expressed in monocytes, and to a lesser extent in granulocytes and lymphocytes. Not expressed in non hematopoietic tissues except in lung. Post-translational modifications: May be phosphorylated on tyrosines. Similarity: Contains 1 SH3 domain. Database links: Entrez Gene: 84106 Human Omim: 606466 Human SwissProt: Q96QH2 Human Unigene: 465812 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
急性早幼粒细胞白血病可通过维甲酸治疗获得完全缓解，而PML-RAR-a(早幼粒细胞白血病-维甲酸受体α融合蛋白)在介导白血病细胞中的维甲酸作用中起重要作用。维甲酸诱导基因PRAM-1(PML-RAR-编码适配子分子1的靶基因)编码在正常人骨髓生成过程中表达和调节的适配子蛋白。PRAM-1的表达受到PML-RAR-a表达的抑制，该蛋白含有8个N端富含脯氨酸的重复序列和几个脯氨酸残基，它们被聚类为Ⅰ型或Ⅱ型SH3识别基序。PRAM-1在造血组织中的表达