Anti-DOK4 Polyclonal Antibody
品牌：solarbio | 货号：K001609P
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K001609P-50ul
solarbio
50ul
960.00元
K001609P-100ul
solarbio
100ul
1600.00元

英文名称
Anti-DOK4 Polyclonal Antibody
别名
IRS-5;IRS5
应用
WB IF
稀释比例
WB 1:500-2000. IF 1:50-200.
交叉反应
Human Mouse Rat
蛋白分子量
37kDa
Gene ID
55715
保存
Store at -20°C. Avoid freeze / thaw cycles.
储存液
Buffer: PBS with 0.02% sodium azide, 50% glycerol, 
pH7.3.
纯化方法
Affinity purification
亚型
IgG
免疫原
Recombinant Protein of human DOK4
性状
液体
Public 
Immunogen 
Range
Recombinant Protein of human DOK4
Subcellular 
Locations
Cytosol
Swiss Prot
Q8TEW6
克隆类型
Polyclonal Antibody
背景资料
The downstream of kinase family (Dok-1-7) are 
members of a class of docking proteins that interact 
with receptor tyrosine kinases and, via this interaction, 
mediate biological responses within the body. Dok-4 
(Downstream of kinase-4) is a 326 amino acid protein 
that contains one PH domain and one IRS-type PTB 
domain and belongs to the Dok family of interacting 
proteins. Expressed in a variety of tissues with highest 
expression in liver, heart, kidney and skeletal muscle, 
Dok-4 plays an important role in Ret-mediated neurite 
outgrowth and may link Ret with downstream effectors 
during neuronal differentiation. Additionally, Dok-4 is 
thought to play a positive role in the activation of 
MAPK pathways and may participate in T-cell induced 
immune system regulation. Overexpression of Dok-4 is 
associated with clear cell renal cell carcinoma, 
suggesting a role for Dok-4 in tumorigenesis.