NCF4 purified MaxPab rabbit polyclonal antibody (D01P)
产品名称： NCF4 purified MaxPab rabbit polyclonal antibody (D01P)
英文名称： NCF4 purified MaxPab rabbit polyclonal antibody (D01P)
产品编号： H00004689-D01P
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against a full-length human NCF4 protein.
- Immunogen:
- NCF4 (NP_000622.2, 1 a.a. ~ 339 a.a) full-length human protein.
- Sequence:
- MAVAQQLRAESDFEQLPDDVAISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYRQFHALQSKLEERFGPDSKSSALACTLPTLPAKVYVGVKQEIAEMRIPALNAYMKSLLSLPVWVLMDEDVRIFFYQSPYDSEQVPQALRRLRPRTRKVKSVSPQGNSVDRMAAPRAEALFDFTGNSKLELNFKAGDVIFLLSRINKDWLEGTVRGATGIFPLSFVKILKDFPEEDDPTNWLRCYYYEDTISTIKDIAVEEDLSSTPLLKDLLELTRREFQREDIALNYRDAEGDLVRLLSDEDVALMVRQARGLPSQKRLFPWKLHITQKDNYRVYNTMP
- Host:
- Rabbit
- Reactivity:
- Human
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody reactive against mammalian transfected lysate.
- MSDS:
Download
- Applications
- Western Blot (Transfected lysate)
- Western Blot analysis of NCF4 expression in transfected 293T cell line (H00004689-T02) by NCF4 MaxPab polyclonal antibody.
Lane 1: NCF4 transfected lysate(39.00 KDa).
Lane 2: Non-transfected lysate. - Protocol Download
- Entrez GeneID:
- 4689
- GeneBank Accession#:
- NM_000631
- Protein Accession#:
- NP_000622.2
- Gene Name:
- NCF4
- Gene Alias:
- MGC3810,NCF,P40PHOX,SH3PXD4
- Gene Description:
- neutrophil cytosolic factor 4, 40kDa
- Omim ID:
- 601488
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq
- Other Designations:
- OTTHUMP00000028736,OTTHUMP00000043756,neutrophil NADPH oxidase factor 4,neutrophil cytosol factor 4,neutrophil cytosolic factor 4
- Gene Pathway
- Related Disease
- Asthma
- Birth Weight
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Cardiovascular Diseases
- Colitis, Ulcerative
- Crohn Disease
- Crohn's disease
- Diabetes Mellitus, Type 2
- Edema
- Genetic Predisposition to Disease
- Glioblastoma
- Glioma
- HIV Infections
- Ileal Diseases
- Leukemia
- Leukemia, Myeloid, Acute
- Lung Diseases