FITC标记的肠道分化干细胞MATH-1蛋白抗体
产品名称： FITC标记的肠道分化干细胞MATH-1蛋白抗体
英文名称： Anti-MATH1/FITC
产品编号： HZ-3522R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-MATH1/FITC Conjugated antibody
FITC标记的肠道分化干细胞MATH-1蛋白抗体
| 英文名称 | Anti-MATH1/FITC |
| 中文名称 | FITC标记的肠道分化干细胞MATH-1蛋白抗体 |
| 别 名 | ATH 1; ATH1; ATOH 1; ATOH1; Atonal homolog 1; Atonal protein homolog 1; HATH 1; HATH1; Helix loop helix protein hATH 1; MATH 1; MATH1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 发育生物学 神经生物学 干细胞 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 38kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MATH1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Drosophila atonal gene produces a protein with basic helix loop helix (bHLH) domains that plays an essential role in the development of the Drosophila nervous system. Mammalian atonal homolog 1 (MATH-1) is a helix-loop-helix (HLH) transcription factor that is structurally homologous to the product of the Drosophila proneural gene atonal. MATH-1, so known as Atoh1, Ath1 or HATH-1, is a 351 amino acid protein with an atonal-related basic HLH domain. In mice, expression of MATH-1 takes place by embryonic day 9.5 and initially localizes to the cranial ganglions and the dorsal part of the central nervous system. Prominent expression of MATH-1 is in the dorsal part of the central nervous system but becomes restricted to the external granular layer of the cerebellum by day 18 and is undetectable in the adult nervous system. It is suggested that MATH-1 may play a role in the differentiation of subsets of neural cells by activating E box-dependent transcription. Function: MATH1 protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. MATH1 is neural-specific and is switched on during differentiation into neuroectoderm. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. May play a role in the differentiation of subsets of neural cells by activating E box-dependent transcription. Subcellular Location: Nucleus. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. Database links: Entrez Gene: 474 Human Entrez Gene: 11921 Mouse Entrez Gene: 500156 Rat Omim: 601461 Human SwissProt: Q92858 Human SwissProt: P48985 Mouse Unigene: 532680 Human Unigene: 57229 Mouse Unigene: 218507 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
果蝇无定形基因产生一种具有基本螺旋-环-螺旋（BHLH）结构域的蛋白质，其在果蝇神经系统的发育中起着至关重要的作用。哺乳动物无调同源物1（MATH-1）是一种螺旋环螺旋（HLH）转录因子，其结构与果蝇原代基因ATONOND的结构同源。MATH-1，被称为ATOH1，Ath1或HAth-1，是一个351氨基酸的蛋白质，与无环相关的基本HLH结构域。在小鼠中，MATH-1的表达发生在胚胎第9.5天，最初定位于颅神经节和中枢神经系统的背侧部分。MATH-1的显著表达在中枢神经系统的背侧，但在第18天仅限于小脑的外颗粒层，在成人神经系统中是不可检测的。提示MATH-1可能通过激活E盒依赖性转录在神经细胞亚群的分化中发挥作用。