FITC标记的细胞死亡调节蛋白抗体(凋亡、半胱胺酸蛋白酶激活抑制剂)
产品名称： FITC标记的细胞死亡调节蛋白抗体(凋亡、半胱胺酸蛋白酶激活抑制剂)
英文名称： Anti-AVEN/FITC
产品编号： HZ-2438R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-AVEN/FITC Conjugated antibody
FITC标记的细胞死亡调节蛋白抗体(凋亡、半胱胺酸蛋白酶激活抑制剂)
| 英文名称 | Anti-AVEN/FITC |
| 中文名称 | FITC标记的细胞死亡调节蛋白抗体(凋亡、半胱胺酸蛋白酶激活抑制剂) |
| 别 名 | 1700013A01Rik; 1700056A21Rik; mAven L; mAven S; MGC124011; Apoptosis caspase activation inhibitor; Cell death regulator Aven; OTTMUSP00000016129; PDCD12; Programmed cell death 12; RP23-52C15.2; AVEN_HUMAN |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 细胞凋亡 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 38kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human AVEN |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. AVEN is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that AVEN functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that AVEN impedes Apaf-1-mediated caspase activation. Higher levels of AVEN mRNA are seen in patients with acute leukemia than in control patients, suggesting that AVEN may be useful as a prognostic indicator in leukemia patients. Function: Protects against apoptosis mediated by Apaf-1 Subunit: Binds Apaf-1, BCL-2 and BAD (Bcl-xl) Subcellular Location: Endomembrane system; Peripheral membrane protein. Note=Associated with intracellular membranes. Tissue Specificity: Highly expressed in testis, ovary, thymus, prostate, spleen, small intestine, colon, heart, skeletal muscle, liver, kidney and pancreas. Database links: Entrez Gene: 57099 Human Entrez Gene: 74268 Mouse Entrez Gene: 311299 Rat Omim: 605265 Human SwissProt: Q9NQS1 Human SwissProt: Q9D9K3 Mouse Unigene: 555966 Human Unigene: 315125 Mouse Unigene: 436657 Mouse Unigene: 145049 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
细胞凋亡在正常机体发育、组织稳态和损伤细胞的清除中起着重要作用。这一过程的破坏与多种疾病有关，如癌症。AvEN是最近发现的一种阻断APAF-1和caspase9诱导的细胞凋亡的蛋白质。据认为，AvEN通过结合Bcl-XL，Bcl-2家族的抗凋亡成员和APAF-1，可能干扰APAF-1自结合能力，这表明AvEN阻碍APAF-1介导的caspase活化。急性白血病患者的AvEN mRNA水平高于对照组，提示AvEN可作为白血病患者的预后指标。