TGFBR1 Pre-design Chimera RNAi
产品名称： TGFBR1 Pre-design Chimera RNAi
英文名称： TGFBR1 Pre-design Chimera RNAi
产品编号： H00007046-R04
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
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- Specification
- Product Description:
- Homo sapiens transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) (TGFBR1), mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_004612
- Target Region:
- Coding sequence
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 7046
- Gene Name:
- TGFBR1
- Gene Alias:
- AAT5,ACVRLK4,ALK-5,ALK5,LDS1A,LDS2A,SKR4,TGFR-1
- Gene Description:
- transforming growth factor, beta receptor 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- OTTHUMP00000021783,activin A receptor type II-like kinase, 53kD,activin A receptor type II-like kinase, 53kDa,activin receptor-like kinase 5,serine/threonine-protein kinase receptor R4,transforming growth factor beta receptor I,transforming growth factor,
- Related Disease
- Abnormalities, Multiple
- Adenocarcinoma
- Adenoma
- Aneurysm, Dissecting
- Aortic Aneurysm, Abdominal
- Aortic Aneurysm, Thoracic
- Aortic Rupture
- Asthma
- Asthma
- Atherosclerosis
- Behcet Syndrome
- Bone Neoplasms
- Breast cancer
- Breast Neoplasms
- Bronchiolitis, Viral
- Carcinoma, Ductal, Breast
- Carcinoma, Lobular
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Renal Cell