FITC标记的胚胎外精子同源蛋白1抗体
产品名称： FITC标记的胚胎外精子同源蛋白1抗体
英文名称： Anti-ESX1/FITC
产品编号： HZ-14639R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ESX1/FITC Conjugated antibody
FITC标记的胚胎外精子同源蛋白1抗体
| 英文名称 | Anti-ESX1/FITC |
| 中文名称 | FITC标记的胚胎外精子同源蛋白1抗体 |
| 别 名 | Epx; ESX1; ESX1_HUMAN; ESX1L; ESXR1; Etx; Extraembryonic; Extraembryonic spermatogenesis homeobox 1; homeobox 1; Homeobox protein ESX1-C; spermatogenesis; Spx1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 发育生物学 信号转导 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 44kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ESX1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis. [provided by RefSeq, Jan 2010] Function: May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover. Subcellular Location: Cytoplasm. Nucleus. ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm. Tissue Specificity: Expressed in placenta and testis. Expressed in testicular germ cell tumors. Post-translational modifications: Undergoes proteolytic cleavage; produces a 45 kDa N-terminal homeodomain-containing fragment (ESXR1-N) and a 20 kDa C-terminal fragment (ESXR1-C). Similarity: Contains 1 homeobox DNA-binding domain. Database links: Entrez Gene: 80712 Human Omim: 300154 Human SwissProt: Q8N693 Human Unigene: 223782 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码双功能65 kDa蛋白，经历蛋白水解裂解产生45 kDa的N-末端片段，具有成对的同源结构域和20 kDa的C-末端片段，具有富含脯氨酸的结构域。C-末端片段定位于细胞质，而N-末端片段仅定位于细胞核。与人相比，小鼠同源物在C末端具有新的PN/PF基序，并在胎盘组织中亲本印迹。该基因可能在胎盘发育和精子发生中起作用。[ RefSeq，2010月1日]