APAF1 monoclonal antibody, clone 2E12
产品名称： APAF1 monoclonal antibody, clone 2E12
英文名称： APAF1 monoclonal antibody, clone 2E12
产品编号： MAB3406
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rat monoclonal antibody raised against partial recombinant APAF1.
- Immunogen:
- Recombinant Flag fusion protein corresponding to amino acids 1-464 of human APAF1.
- Host:
- Rat
- Reactivity:
- Human
- Specificity:
- Recognizes the CARD domain of human Apaf-1. Does not cross-react with mouse or rat Apaf-1.
- Form:
- Liquid
- Isotype:
- IgG2a
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Application Image
- Western Blot
- Immunohistochemistry (Frozen sections)
- Immunocytochemistry
- Immunoprecipitation
- ELISA
- Entrez GeneID:
- 317
- Gene Name:
- APAF1
- Gene Alias:
- CED4,DKFZp781B1145
- Gene Description:
- apoptotic peptidase activating factor 1
- Omim ID:
- 602233
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq
- Other Designations:
- apoptotic protease activating factor 1
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